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Everything You Must Know About AMPK Activators
To ensure that the body is functioning properly, AMPK is crucial as it is regulating the maintenance of cellular energy homeostasis. Now in mammals, AMPK is regulating the energy balance at both on cellular level by means of sensing ATP/AMP and ATP/ADP ratio levels and whole body level through response to the hormones and the brain.
ATP is actually the most significant energy molecule present in the body. In essence, this is the starting point of cellular function. Because energy is being used by cells, ATP is breaking down into ADP which has less potential for energy. ADP is then broken down to AMP which has contains the least energy potential among all 3. In reality, this is where AMPK is used; it senses the ratios of ATP/ADP/AMP and it tells the body if it requires more ADP so by that, it will be able to maintain optimal functions.
AMPK acts on various processes through different mechanisms. Since the AMPK is considered as the master regulator for all functioning cells, it just makes sense. The effect that AMPK activation in the body depend on the complicated balance of factors and the signaling pathways. Still, there are many different benefits of having increased AMPK and these are:
Anti aging – AMPK activation is gradually declining as we are aging. Some experts think that AMPK is among the contributing factors for aging. This promotes cellular renewal and at the same time, production of new mitochondria.
Anti inflammation – interestingly enough, AMPK activation can help in decreasing inflammation but it can be decreased as well by inflammation.
Anti diabetic – the truth is, AMPK is becoming more and more understood when it comes to its role in diabetes treatment mainly because of the ability it has in enhancing insulin sensitivity.
Basically, there are more and more nutritional products and herbal products/constituents discovered that are very effective in AMPK activator to which some include:
Number 1. AICAR – in AMP, AICAR is considered as its analog that is necessary for cellular use and storage similar to ATP. AICAR has been studied and discovered to directly affect AMPKs activity that helps it to improve muscle performance all because it’s the analog of AMP.
Number 2. ALA – this is an abbreviation for Alpha Lipoic Acid that is a powerful AMPK activator and at the same time, popular for its effective antioxidant content. It has been shown to greatly boost insulin sensitivity in the body and carrying anti obesity effects.
Number 3. Green tea extract – this helps in activating upstream kinase which then helps in activating AMPK.
Number 4. Berberine – with AMPK activation, berberine was known to bring the same anti diabetic effect as metformin.